Omega-6 (Vegetable Oil) Harmful (N=500, P=.05, Large Effect)
As these studies go, it was relatively small, only about 500 subjects. The main results:
Compared with the control group, the intervention group had an increased risk of all cause mortality (17.6% v 11.8%[emphasis added]; hazard ratio 1.62 (95% confidence interval 1.00 to 2.64); P=0.051), cardiovascular mortality (17.2% v 11.0%; 1.70 (1.03 to 2.80); P=0.037), and mortality from coronary heart disease (16.3% v 10.1%; 1.74 (1.04 to 2.92); P=0.036).
A 50% increase in death rate! The safflower oil was so damaging that even this small study yielded significant differences.
The authors go on to show that this result (omega-6 is bad for you) is supported by other studies. Walter Willett and countless other experts were quite wrong on the biggest health issue of our time (how to reduce heart disease, the #1 cause of death).