Mostly Good Traits
| Who | Genotype | What It Means |
|---|---|---|
| Jonathan Graehl | CC | Two working copies of alpha-actinin-3 in fast-twitch muscle fiber.Many world-class sprinters and some endurance athletes have this genotype. |
I’m fast-twitchy. breast-fed as a baby:
| Who | Genotype | What It Means |
|---|---|---|
| Jonathan Graehl | CC | Being breastfed raised subjects’ IQ by 6-7 points on average. |
| Who | Genotype | What It Means |
|---|---|---|
| Jonathan Graehl | AA | Being breastfed raised subjects’ IQ by 4-5 points on average. |
negative reinforcement works well on me (also linked in general to having more dopamine receptors and maybe being susceptible to heroin addiction):
| Who | Genotype | What It Means |
|---|---|---|
| Jonathan Graehl | GG | Effectively learns to avoid errors. |
better memory (of word sequences/events):
| Jonathan Graehl | CT | Slightly increased episodic memory. |
fatty diet won’t make me fat:
| Jonathan Graehl | AG | No change in BMI with a high-fat diet. |
I have testosterone:
| Who | Genotype | What It Means |
|---|---|---|
| Jonathan Graehl | AA | Typical levels of circulating testosterone. |
I can diet:
| Who | Genotype | What It Means |
|---|---|---|
| Jonathan Graehl | AA | Decreasing energy intake and increasing physical activity was associated with weight loss |
average longevity:
| Jonathan Graehl | AC | Typical odds of living to 100. |
not susceptible to cigarette addiction:
| Who | Genotype | What It Means |
|---|---|---|
|
|
AA | In Europeans who smoke, likely to smoke two more cigarettes per day on average than the typical amount. |
|
|
AG | In Europeans who smoke, likely to smoke one more cigarette per day on average than the typical amount. |
| Jonathan Graehl | GG | In Europeans who smoke, likely to smoke the typical number of cigarettes per day. |
50% normal risk of psoriasis
75% normal risk of melanoma
50% normal risk of rhematoid arthritis
20% normal risk of age related vision loss
320% normal risk of venous thromboembolism (blood clot -> possible pulmonary embolism / stroke). Fortunately, it seems like there are easily controllable lifestyle factors, and you can detect a clot before it breaks off and causes stroke. (DVT/PE is a lifetime 12% risk for normal people, 40% for me!)
- DVT (leg clot) symptoms:
- Swelling, usually in one leg
- Leg pain or tenderness
- Reddish or bluish skin discoloration
- Leg warm to touch
- PE (lung clot) symptoms:
- Sudden shortness of breath
- Chest pain-sharp, stabbing; may get worse with deep breath
- Rapid heart rate
- Unexplained cough, sometimes with bloody mucus
Don’t smoke
A large Danish study found that women who smoked had a 52% increased risk for venous thromboembolism compared with women who had never smoked. For men, smoking conferred a 32% increase in risk. Heavy smokers had even higher risks.
Keep your weight in check
Obesity increases the risk of venous thromboembolism.
Get up and move
Venous thromboembolism is sometimes called “economy class syndrome” because sitting still for long periods of time, as on a cramped airplane, can cause sluggish blood flow, which in turn increases the risk for the formation of blood clots.